Journal Articles
306. LM Rad, KR Hughes, SN Wheeler, JT Decker, SM Orbach, A Galvan, J Thornhill, KV Griffin, H Turkistani, RR Urie, DN Irani, LD Shea, AH Morris. Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis. Proc Natl Acad Sci USA. 2025.
305. Xu Z, Escalona G, Schrack I, Zhang W, Zhai T, Shea LD, Wang X. Detecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasive in vivo photoacoustic microscopy and optical coherence tomography. Theranostics. 2025.
304. Urie RR, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li JZ, Goldstein DR, Shea LD. Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts. Sci Adv. 2024.
303. Saunders MN, Rival CM, Mandal, M, Cramton K, Rad LM, Janczak KW, Williams LA, Angadi AR, O’Konek JJ, Shea LD, Erickson LD. Immunotherapy with biodegradable nanoparticles encapsulating the oligosaccharide galactose-alpha-1,3-galactose enhance immune tolerance against alpha-gal sensitization in a murine model of alpha-gal syndrome. Front Allergy. 2024.
302. Saunders MN, Rad LM, Williams LA, Landers JJ, Urie RR, Hocevar SE, Quiros M, Chiang MY, Angadi AR, Janczak KW, Bealer EJ, Crumley K, Benson OE, Griffin KV, Ross BC, Parkos CA, Nusrat A, Miller, SD, Podojil JR, O’Konek KK, hea LD. Allergen-Encapsulating Nanoparticles Reprogram Pathogenic Allergen-Specific Th2 Cells to Suppress Food Allergy. Adv Healthc Mater. 2024.
301. Ross BC, Kent 3rd RN, Saunders MN, Schwartz SR, Smiley BM, Hocevar SE, Chen SC, Xiao C, Williams LA, Anderson AJ, Cummings, BJ, Baker BM, Shea LD. Building-Block Size Mediates Microporous Annealed Particle Hydrogel Tube Microenvironment Following Spinal Cord Injury. Adv Healthc Mater. 2024.
300. Raghani RM, Urie RR, Ma JA, Escalona G, Schrack IA, DiLillo KM, Kandagatla P, Decker JT, Morris AH, Arnold KB, Jeruss JS, Shea LD. Engineered Immunologic Niche Monitors Checkpoint Blockade Response and Probes Mechanisms of Resistance. Immunomedicine. 2024.
299. Rad LM, Arellano G, Podojil JR, O’Konek JJ, Shea LD, Miller SD. Engineering nanoparticle therapeutics for food allergy. J Allergy Clin Immunol. 2024.
298. Lietzke AC, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D’Ancona E, Henry-Kanarek B, Reck EC, Arnipalli M, Sidarala V, Walker EM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA. Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived beta cells. bioRxiv. 2024.
297. King JL, Urie RR, Morris AH, Rad L, Bealer E, Kasputis T, Shea LD. Polymer scaffolds delineate healthy from diseased states at sites distal from the pancreas in two models of type 1 diabetes. Biotechnol Bioeng. 2024.
296. Griffin KV, Saunders MN, Lyssiotis CA, Shea LD. Engineering immunity using metabolically active polymeric nanoparticles. Trends Biotechnol. 2024.
295. Escalona G, Ocadiz-Ruiz R, Ma JA, Schrack IA, Ross BC, Morrison AK, Jeruss JS, Shea LD. Design Principles of an Engineered Metastatic Niche for Monitoring of Cancer Progression. Biotechnol Bioeng. 2024.
294. Decker JT, Hall MS, Nanua D, Orbach SM, Roy J, Angadi A, Caton J, Hesse L, Jeruss JS, Shea LD. Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy. Cell Mol Bioeng. 2024.
293. Subramaniam S, Akay M, Anastasio MA, Bailey V, Boas D, Bonato P, Chilkoti A, Cochran JR, Colvin V, Desai TA, Duncan JS, Epstein FH, Fraley S, Giachelli C, Grande-Allen KJ, Green J, Guo XE, Hilton IB, Humphrey JD, Johnson CR, Karniadakis G, King MR, Kirsch RF, Kumar S, Laurencin CT, Li S, Lieber RL, Lovell N, Mali P, Margulies SS, Meaney DF, Ogle B, Palsson B, Peppas NA, Perreault EJ, Rabbitt R, Setton LA, Shea LD, Shroff SG, Shung K, Tolias AS, Van der Meulen MCH, Varghese S, Vunjak-Novakovic G, White JA, Winslow R, Zhang J, Zhang K, Zukoski C, Miller MI. Grand Challenges at the Interface of Engineering and Medicine. IEEE Open J Eng Med Biol. 2024
292. Ocadiz-Ruiz R, Decker JT, Griffin K, Tan ZM, Domala NK, Jeruss JS, Shea LD. Human Breast Cancer Cell Lines Differentially Modulate Signaling from Distant Microenvironments, Which Reflects Their Metastatic Potential. Cancers (Basel). 2024
291. Saunders MN, Griffin KV, Kalashnikova I, Kolpek D, Smith DR, Saito E, Cummings BJ, Anderson AJ, Shea LD, Park J. Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury. Pain. 2024
290. Nekanti U, Sakthivel P, Zahedi A, Creasman DA, Nishi RA, Dumont CM, Piltti KM, Guardamondo GL, Hernandez N, Chen X, Song H, Lin X, Martinez J, On L, Lakatos A, Pawar K, David BT, Guo Z, Seidlits SK, Xu X, Shea LD, Cummings BJ, Anderson AJ. Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI. NPJ Regen Med. 2024.
289. Orbach SM, DeVaull CY, Bealer EJ, Ross BC, Jeruss JS, Shea LD. An engineered niche delineates metastatic potential of breast cancer. Bioeng Transl Med. 2023.
288. Wang J, Ocadiz-Ruiz R, Hall MS, Bushnell GG, Orbach SM, Decker JT, Raghani RM, Zhang Y, Morris AH, Jeruss JS, Shea LD. A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs. Nature Communications. 2023.
287. Urie RR, Xiao C, Hughes E, Lombard E, Chen J, Morris A, Farris D, Goldstein D, Shea LD. Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection. J Immunol. 2023.
286. Decker AM, Matsumoto M, Decker JT, Roh A, Inohara N, Sugai J, Martin K, Taichman R, Kaigler D, Shea LD, Nunez G. Inhibition of Mertk Signaling Enhances Bone Healing after Tooth Extraction. J Dent Res. 2023.
285. Li F, Li F, Urie R, Bealer E, Ocadiz-Ruiz R, Saito E, Turan A, Yolcu E, Shirwan H, Shea LD. Membrane-coated nanoparticles for direct recognition by T cells. Biotechnol Bioeng. 2023.
284. Bealer E, Crumley K, Clough D, King J, Behrend M, Annulis C, Li F, Soleimanpour S, Shea LD. Extrahepatic transplantation of 3D cultured stem cell-derived islet organoids on microporous scaffolds. Biomater Sci. 2023.
283. Casey LM, Decker JT, Podojil JR, Rad L, Hughes KR, Rose JA, Pearson RM, Miller SD, Shea LD. Nanoparticle dose and antigen loading attenuate antigen-specific T-cell responses. Biotechnol Bioeng. 2023.
282. Babayev E, Xu M, Shea LD, Woodruff TK, Duncan FE. Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth. Mol Hum Reprod. 2022.
281. Podojil JR, Cogswell AC, Chiang MY, Eaton V, Ifergan I, Neef T, Xu D, Meghani KA, Yu Y, Orbach SM, Murthy T, Boyne MT, Elhofy A, Shea LD, Meeks JJ, Miller SD. Biodegradable nanoparticles induce cGAS/STING-dependent reprogramming of myeloid cells to promote tumor immunotherapy. Front Immunol. 2022.
280. Dye BR, Decker JT, Hein RFC, Miller AJ, Huang S, Spence JR, Shea LD. Human Lung Organoid Culture in Alginate With and Without Matrigel to Model Development and Disease. Tissue Eng Part A. 2022.
279. Orbach SM, Brooks MD, Zhang Y, Campit SE, Bushnell GG, Decker JT, Rebernick RJ, Chandrasekaran S, Wicha MS, Jeruss JS, Shea LD. Correction: Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer. Clin Exp Metastasis. 2024.
278. Raghani RM, Ma JA, Zhang Y, Orbach SM, Wang J, Zeinali M, Nagrath S, Kakade S, Xu Q, Podojil JR, Murthy T, Elhofy A, Jeruss JS, Shea LD. Myeloid cell reprogramming alleviates immunosuppression and promotes clearance of metastatic lesions. Front Oncol. 2022.
277. Li F, Crumley K, Bealer E, King JL, Saito E, Grimany-Nuno O, Yolcu ES, Shirwan H, Shea LD. Fas Ligand-Modified Scaffolds Protect Stem Cell Derived beta-Cells by Modulating Immune Cell Numbers and Polarization. ACS Appl Mater Interfaces. 2022.
276. Hughes KR, Saunders MN, Landers JJ, Janczak KW, Turkistani H, Rad LM, Miller SD, Podojil JR, Shea LD, O’Konek JJ. Masked Delivery of Allergen in Nanoparticles Safely Attenuates Anaphylactic Response in Murine Models of Peanut Allergy. Front Allergy. 2022.
275. Larouche JA, Fraczek PM, Kurpiers SJ, Yang BA, Davis C, Castor-Macias JA, Sabin K, Anderson S, Harrer J, Hall M, Brooks SV, Jang YC, Willett N, Shea LD, Aguilar CA. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci USA. 2022.
274. Casey LM, Hughes KR, Saunders MN, Miller SD, Pearson RM, Shea LD. Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance. Biomaterials. 2022.
273. Neef T, Ifergan I, Beddow S, Penaloza-MacMaster P, Haskins K, Shea LD, Podojil JR, Miller SD. Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4+ and CD8+ T Cells. Cells. 2021.
272. Decker JT, Ma JA, Shea LD, Jeruss JS. Implications of TGFβ Signaling and CDK Inhibition for the Treatment of Breast Cancer. Cancers (Basel). 2021.
271. Krentz NAJ, Shea LD, Huising MO, Shaw JAM. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes Endocrinol. 2021.
270. Ciciriello AJ, Smith DR, Munsell MK, Boyd SJ, Shea LD, Dumont CM. IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury. Biotechnol Bioeng. 2021.
269. Kemp SB, Steele NG, Carpenter ES, Donahue KL, Bushnell GG, Morris AH, The S, Orbach SM, Sirihorachai VR, Nwosu ZC, Espinoza C, Lima F, Brown K, Girgis AA, Gunchick V, Zhang Y, Lyssiotis CA, Frankel TL, Bednar F, Rao A, Sahai V, Shea LD, Crawford HC, Pasca di Magliano M. Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages. Life Sci Alliance. 2021.
268. Zhang Y, Hughes KR, Raghani RM, Ma J, Orbach S, Jeruss JS, Shea LD. Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer. Biomaterials. 2021.
267. Bushnell GG, Orbach SM, Ma JA, Crawford HC, Wicha MS, Jeruss JS, Shea LD. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2020.
266. Ciciriello AJ, Smith DR, Munsell MK, Boyd SJ, Shea LD, Dumont CM. Acute Implantation of Aligned Hydrogel Tubes Supports Delayed Spinal Progenitor Implantation. ACS Biomater Sci Eng. 2020.
265. Saito E, Gurczynski SJ, Kramer KR, Wilke CA, Miller SD, Moore BB, Shea LD. Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease. Sci Adv. 2020.
264. Decker JT, Kandagatla P, Wan L, Bernstein R, Ma JA, Shea LD, Jeruss JS. Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer. Cancer Biol Ther. 2020.
263. Chen JY, Fu EJ, Patel PR, Hostetler AJ, Sawan HA, Moss KA, Hocevar SE, Anderson AJ, Chestek CA, Shea LD. Lentiviral Interleukin-10 Gene Therapy Preserves Fine Motor Circuitry and Function After a Cervical Spinal Cord Injury in Male and Female Mice. Neurotherapeutics. 2020.
262. Zuidema JM, Dumont CM, Wang J, Batchelor WM, Lu YS, Kang J, Bertucci A, Ziebarth NM, Shea LD, Sailor MJ. Porous Silicon Nanoparticles Embedded in Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth. Adv Funct Mater. 2020.
261. Clough DW, King JL, Li F, Shea LD. Integration of Islet/Beta-Cell Transplants with Host Tissue Using Biomaterial Platforms. Endocrinology. 2020.
260. Biancotti JC, Walker KA, Jiang G, Di Bernardo J, Shea LD, Kunisaki SM. Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair. J Tissue Eng. 2020.
259. Morris AH, Hughes KR, Oakes RS, Cai MM, Miller SD, Irani DN, Shea LD. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
258. Youngblood R, Flesher CG, Delproposto J, Baker NA, Neeley CK, Li F, Lumeng CN, Shea LD, O’Rourke RW. Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin-4. Biotechnol Bioeng. 2020.
257. Safari H, Kelley WJ, Saito E, Kaczorowski N, Carethers L, Shea LD, Eniola-Adefeso O. Neutrophils preferentially phagocytose elongated particles-An opportunity for selective targeting in acute inflammatory diseases. Sci Adv. 2020.
256. Hall MS, Decker JT, Shea LD. Towards systems tissue engineering: Elucidating the dynamics, spatial coordination, and individual cells driving emergent behaviors. Biomaterials. 2020.
255. Morris AH, Orbach SM, Bushnell GG, Oakes RS, Jeruss JS, Shea LD. Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine. Cancer Res. 2020.
254. Decker AM, Decker JT, Jung Y, Cackowski FC, Daignault-Newton S, Morgan TM, Shea LD, Taichman RS. Adrenergic Blockade Promotes Maintenance of Dormancy in Prostate Cancer Through Upregulation of GAS6. Transl Oncol. 2020.
253. Ali SA, Hanks JE, Stebbins AW, Alkhalili O, Cohen ST, Chen JY, Smith DR, Dumont CM, Shea LD, Hogikyan ND, Feldman EL, Brenner MJ. Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration. Laryngoscope. 2020.
252. Freitag TL, Podojil JR, Pearson RM, Fokta FJ, Sahl C, Messing M, Andersson LC, Leskinen K, Saavalainen P, Hoover LI, Huang K, Phippard D, Maleki S, King NJC, Shea LD, Miller SD, Meri SK, Getts DR. Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease. Gastroenterology. 2020.
251. Bushnell GG, Hong X, Hartfield RM, Zhang Y, Oakes RS, Rao SS, Jeruss JS, Stegemann JP, Deng CX, Shea LD. High Frequency Spectral Ultrasound Imaging to Detect Metastasis in Implanted Biomaterial Scaffolds. Ann Biomed Eng. 2020.
250. Smith DR, Dumont CM, Park J, Ciciriello AJ, Guo A, Tatineni R, Cummings BJ, Anderson AJ, Shea LD. Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. Tissue Eng Part A. 2020.
249. Dye BR, Youngblood RL, Oakes RS, Kasputis T, Clough DW, Spence JR, Shea LD. Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties. Biomaterials. 2020.
248. Bernabé BP, Woodruff T, Broadbelt LJ, Shea LD. Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development. Reprod Sci. 2020.
247. Smith DR, Dumont CM, Ciciriello AJ, Guo A, Tatineni R, Munsell MK, Cummings BJ, Anderson AJ, Shea LD. PLG Bridge Implantation in Chronic SCI Promotes Axonal Elongation and Myelination. ACS Biomater. Sci. Eng. 2019.
246. Oakes RS, Bushnell GG, Orbach SM, Kandagatla P, Zhang Y, Morris AH, Hall MS, LaFaire P, Decker JT, Hartfield RM, Brooks MD, Wicha MS, Jeruss JS, Shea LD. Metastatic conditioning of myeloid cells at subcutaneous synthetic niche reflects disease progression and predicts therapeutic outcomes. Cancer Res. 2020.
245. Bushnell GG, Wicha MS, Jeruss JS, Shea LD. Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression. Invited Editorial, Oncoscience. 2019.
244. Bushnell GG, Rao SS, Hartfield RM, Zhang Y, Oakes RS, Jeruss JS, Shea LD. Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo. Biotechnology and Bioengineering. 2019.
243. Saito E, Kuo R, Kramer KR, Gohel N, Giles DA, Moore BB, Miller SD, Shea LD. Design of Biodegradable Nanoparticles to Modulate Phenotypes of Antigen Presenting Cells for Antigen-Specific Treatment of Autoimmune Disease. Biomaterials. 2019.
242. Casey LM, Kakade S, Decker JT, Rose JA, Deans K, Shea LD, Pearson RM. Cargo-less nanoparticles program innate immune cell responses to toll-like receptor activation. Biomaterials. 2019.
241. Day JR, David A, Long C, Bushnell GG, Woodruff TK, Shea LD, Shikanov A. Immuno-Isolating Dual Poly(ethylene glycol) Capsule Prevents Cancer Cells from Spreading Following Mouse Ovarian Tissue Auto-Transplantation. Regen Med Front. 2019.
240. Park J, Zhang Y, Saito E, Gurczynski SJ, Moore BB, Cummings BJ, Anderson AJ, Shea LD. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. Proc Natl Acad Sci USA. 2019.
239. Youngblood RL, Sampson JP, Lebioda KR, Shea LD. Microporous scaffolds support assembly and differentiation of pancreatic progenitors into β-cell clusters. Acta Biomater. 2019.
238. Peñalver Bernabé B, Thiele I, Galdones E, Siletz A, Chandrasekaran S, Woodruff TK, Broadbelt LJ, Shea LD. Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development. BMC Bioinformatics. 2019.
237. Shah S, Daneshmandi S, Hughes KR, Yu S, Bedoya AM, Shea LD, Luo X. Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model. Biomaterials. 2019.
236. Saito E, Kuo R, Pearson RM, Gohel N, Cheung B, King NJC, Miller SD, Shea LD. Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation. J Control Release. 2019.
235. Bushnell GG, Hardas TP, Hartfield RM, Zhang Y, Oakes RS, Ronquist S, Chen H, Rajapakse I, Wicha MS, Jeruss JS, Shea LD. Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor Cells In Vivo. Cancer Res. 2019.
234. Miller AJ, Dye BR, Ferrer-Torres D, Hill DR, Overeem AW, Shea LD, Spence JR. Generation of lung organoids from human pluripotent stem cells in vitro. Nat Protoc. 2019.
233. Dumont CM, Carlson MA, Munsell MK, Ciciriello AJ, Strnadova K, Park J, Cummings BJ, Anderson AJ, Shea LD. Aligned hydrogel tubes guide regeneration following spinal cord injury. Acta Biomater. 2019.
232. Skoumal M, Woodward KB, Zhao H, Wang F, Yolcu ES, Pearson RM, Hughes KR, García AJ, Shea LD, Shirwan H. Localized immune tolerance from FasL-functionalized PLG scaffolds. Biomaterials. 2019.
231. Pearson RM, Podojil JR, Shea LD, King NJC, Miller SD, Getts DR. Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles. Nanomedicine. 2019.
230. Kasputis T, Clough D, Noto F, Rychel K, Dye B, Shea LD. Microporous Polymer Scaffolds for the Transplantation of Embryonic Stem Cell Derived Pancreatic Progenitors to a Clinically Translatable Site for the Treatment of Type I Diabetes. ACS Biomater Sci Eng. 2018.
229. Park J, Decker JT, Smith DR, Cummings BJ, Anderson AJ, Shea LD. Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury. J Control Release. 2018.
228. Smith DR, Margul DJ, Dumont CM, Carlson MA, Munsell MK, Johnson M, Cummings BJ, Anderson AJ, Shea LD. Combinatorial lentiviral gene delivery of pro-oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury. Biotechnol Bioeng. 2019.
227. Dumont CM, Munsell MK, Carlson MA, Cummings BJ, Anderson AJ, Shea LD. Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury. Tissue Eng Part A. 2018.
226. Decker JT, Hall MS, Peñalver-Bernabé B, Blaisdell RB, Liebman LN, Jeruss JS, Shea LD. Design of Large-Scale Reporter Construct Arrays for Dynamic, Live Cell Systems Biology. ACS Synth Biol. 2018.
225. Youngblood RL, Truong NF, Segura T, Shea LD. It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies. Mol Ther. 2018.
224. Decker JT, Hall MS, Blaisdell RB, Schwark K, Jeruss JS, Shea LD. Dynamic miRNA activity identifies therapeutic targets in trastuzumab-resistant HER2+ breast cancer. Biotech and Bioeng. 2018.
223. Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings BJ, Anderson AJ. Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation. J Biomed Opt. 2018.
222. Rios PD, Skoumal M, Liu J, Youngblood R, Kniazeva E, Garcia AJ, Shea LD. Evaluation of Encapsulating and Microporous Non-degradable Hydrogel Scaffold Designs on Islet Engraftment in Rodent Models of Diabetes. Biotech and Bioeng. 2018.
221. Rios PD, Kniazeva E, Lee HC, Xiao S, Oakes RS, Saito E, Jeruss JS, Shikanov A, Woodruff TK, Shea LD. Retrievable Hydrogels for Ovarian Follicle Transplantation and Oocyte Collection. Biotech and Bioeng. 2018.
220. Park J, Decker JT, Margul DJ, Smith DR, Cummings BJ, Anderson AJ, Shea LD. Localized immunomodulation with anti-inflammatory cytokine encoding lentivirus enhances functional regeneration after spinal cord injury. Molecular Therapy. 2018.
219. Kasputis T, Clough D, Noto F, Rychel K, Dye B, Shea LD. Microporous Polymer Scaffolds for the Transplantation of Embryonic Stem Cell Derived Pancreatic Progenitors to a Clinically Translatable Site for the Treatment of Type I Diabetes. ACS Biomaterials Science & Engineering. 2018.
218. Aguado BA, Hartfield RM, Bushnell GG, Decker JT, Azarin SM, Nanavati D, Schipma MJ, Rao SS, Oakes RS, Zhang Y, Jeruss JS, Shea LD. Biomaterial scaffolds as pre-metastatic niche mimics systemically alter the primary tumor and tumor microenvironment. Adv Healthc Mater. 2018.
217. Zhou H, Decker JT, Lemke MM, Tomaszewski CE, Shea LD, Arnold KB, Shikanov A. Correction to: Synergy of Paracrine Signaling During Early-Stage Mouse Ovarian Follicle Development In Vitro. Cell Mol Bioeng. 2018.
216. Roca H., Jones JD, Purica MC, Weidner S, Koh AJ, Kuo R, Wilkinson JE, Wang Y, Daignault-Newton S, Pienta KJ, Morgan TM, Keller ET, Nor JE, Shea LD, McCauley LK. Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone. J Clin Invest. 2018.
215. Prasad S, Neef T, Xu D, Podojil JR, Getts DR, Shea LD, Miller SD. Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells. J Autoimmun. 2018.
214. Cascalho M, Huynh D, Lefferts AR, Stein L, Lanigan T, Decker J, Shea LD, Platt JL. Durable targeting of B-lymphocytes in living mice. Sci Rep. 2018.
213. Liu JMH, Zhang X., Joe S, Luo X, Shea LD. Evaluation of biomaterial scaffold delivery of IL-33 as a localized immunomodulatory agent to support cell transplantation in adipose tissue. .Journal of Immunology and Regenerative Medicine. 2018.
212. Casey LM, Pearson RM, Hughes KR, Liu JMH, Rose JA, North MG, Wang LZ, Lei M, Miller SD, Shea LD. Conjugation of transforming growth factor beta to antigen-loaded poly(lactide-co-glycolide) nanoparticles enhances efficiency of antigen-specific tolerance. Bioconjug Chem. 2018.
211. Tarasewicz E, Oakes RS, Aviles MO, Straehla J, Chilton KM, Decker JT, Wu J, Shea LD, Jeruss JS. Embryonic stem cell secreted factors decrease invasiveness of triple-negative breast cancer cells through regulome modulation. Cancer Biol Ther. 2018.
210. Dye BR, Kasputis T, Spence JR, Shea LD. Take a deep breath and digest the material: organoids and biomaterials of the respiratory and digestive systems. MRS Communications. 2017 Aug 1-13
209. Rao SS, Stoehr J, Dokic D, Wan L, Decker JT, Konopka K, Thomas AL, Wu J, Kaklamani VG, Shea LD, Jeruss JS. Synergistic effect of eribuluin and CDK inhibition for the treatment of triple negative breast cancer. Oncotarget. 2017.
208. Pearson RM, Casey LM, Hughes KR, Wang LZ, North MG, Getts DR, Miller SD, Shea LD. Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates. Mol Ther. 2017.
207. Kuo R, Saito E, Miller SD, Shea LD. Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance. Mol Ther. 2017.
206. Weaver JD, Headen DM, Aquart J, Johnson CT, Shea LD, Shirwan H, García AJ. Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites. Sci Adv. 2017.
205. Pearson RM, Casey LM, Hughes KR, Miller SD, Shea LD. In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance. Adv Drug Deliv Rev. 2017.
204. Wu B, Durisin EK, Decker JT, Ural EE, Shea LD, Coleman RM. Phosphate regulates chondrogenesis in a biphasic and maturation-dependent manner. Differentiation. 2017.
203. Desai T, Shea LD. Advances in islet encapsulation technologies. Nat Rev Drug Discov. 2017.
202. Decker JT, Hobson EC, Zhang Y, Shin S, Thomas AL, Jeruss JS, Arnold KB, Shea LD. Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells. Biotechnol Bioeng. 2017.
201. Aguado BA, Bushnell GG, Rao SS, Jeruss JS, Shea LD. Engineering the pre-metastatic niche. Nat Biomed Eng. 2017.
200. Margul DJ, Park J, Boehler RM, Smith DR, Johnson MA, McCreedy DA, He T, Ataliwala A, Kukushliev TV, Liang J, Sohrabi A, Goodman AG, Walthers CM, Shea LD, Seidlits SK. Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges. Bioeng Transl Med. 2016.
199. McCarthy DP, Yap JW, Harp CT, Song WK, Chen J, Pearson RM, Miller SD, Shea LD. An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy. Nanomedicine. 2017.
198. Dumont CM, Margul DJ, Shea LD. Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury. Cells, Tissues, Organs. 2016.
197. Rios PD, Zhang X, Luo X, Shea LD. Mold-Casted Non-Degradable, Islet Macro-encapsulating Hydrogel Devices for Restoration of Normoglycemia in Diabetic Mice. Biotechnol Bioeng. 2016.
196. Spicer GL, Azarin SM, Yi J, Young ST, Ellis R, Bauer GM, Shea LD, Backman V. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography. Phys Med Biol. 2016.
195. Dye BR, Dedhia PH, Miller AJ, Nagy MS, White ES, Shea LD, Spence JR. A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids. Elife. 2016.
194. Rao SS, Azarin SM, Spicer G, Bushnell GG, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Jeruss JS, Shea LD. Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Cancer Res. 2016.
193. Skoumal M, Seidlits S, Shin S, Shea LD. Localized lentivirus delivery via peptide interactions. Biotechnol Bioeng. 2016.
192. Peñalver Bernabé B, Shin S, Rios PD, Broadbelt LJ, Shea LD, Seidlits SK. Dynamic transcription factor activity networks in response to independently altered mechanical and adhesive microenvironmental cues. Integr Biol (Camb). 2016.
191. Luo X, Miller SD, Shea LD. Immune tolerance for autoimmune disease and cell transplantation. Annu Rev Biomed Eng. 2016.
190. Smarr C, Yap WT, Neef TP, Pearson RM, Hunter ZN, Ifergan I, Getts DR, Bryce PJ, Shea LD, Miller SD. Biodegradable Antigen-Associated PLG Nanoparticles Tolerize Th2 Mediated Allergic Airway Inflammation Pre- and Post-Sensitization. PNAS. 2016.
189. McCreedy D, Margul DJ, Seidlits SK, Antaneb JT, Thomasa RJ, Sissmana GM, Boehler RM, Smith DR, Goldsmithb SW, Kukushliev, TV, Lamano JB, Vedia BH, He T, Shea LD. Semi-Automated Counting of Axon Regeneration in PLG Spinal Cord Bridges. J Neu Method. 2016.
188. Liu JM, Zhang J, Zhang X, Hlavaty KA, Ricci CF, Leonard JN, Shea LD, Gower RM. Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets. Biomaterials. 2016.
187. Aguado BA, Caffe JR, Nanavati D, Rao SS, Bushnell GG, Azarin SM, Shea LD. Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche. Acta Biomater. 2016.
186. Dubash AD, Kam CY, Aguado B, Patel D, Delmar M, Shea LD, Green KJ. Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J Cell Biol. 2016.
185. Hlavaty KA, McCarthy DP, Saito E, Yap WT, Miller SD, Shea LD. Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation. Biomaterials. 2016.
184. Kniazeva E, Hardy AN, Boukaidi SA, Woodruff TK, Jeruss JS, Shea LD. Primordial Follicle Transplantation within Designer Biomaterial Grafts Produce Live Births in a Mouse Infertility Model. Sci Reports. 2015.
183. Dumont CM, Park J, Shea LD. Controlled release strategies for modulating immune responses to promote tissue regeneration. J Control Release. 2015 Dec 10;219:155-66.
182. Xiao S, Zhang J, Smith KN, Shea LD, Woodruff TK. In vitro follicle growth supports human oocyte meiotic maturation. Sci Reports. 2015.
181. Getts DR, Shea LD, Miller SD, King NJ. Harnessing nanoparticles for immune modulation. Trends Immunol. 2015.
180. Aguado BA, Wu JJ, Azarin SM, Nanavanti D, Rao SS, Bushnell GG, Medicherla CB, Shea LD. Secretome identification of immune cell factors mediating metastatic cell homing. Sci Reports. 2015.
179. Thomas AM, Shea LD. Cryotemplation for the rapid fabrication of porous, patternable photopolymerized hydrogels. J Mater Chem B Mater Biol Med. 2014.
178. Thomas AM, Palma JL, Shea LD. Sponge mediated lentivirus delivery to acute and chronic spinal cord injuries. J Control Rel. 2015.
177. Pawar K, Cummings BJ, Thomas A, Shea LD, Levine A, Pfaff S, Anderson AJ. Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function. Biomaterials. 2015.
176. Skory RM, Xu Y, Shea LD, Woodruff TK. Engineering the ovarian cycle using in vitro follicle culture. Hum Reprod. 2015.
175. Hlavaty KA, Luo X, Shea LD, Miller SD. Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. Clin Immunol. 2015.
174. Chen J, White SB, Harris KR, Li W, Yap JW, Kim DH, Lewandowski RJ, Shea LD, Larson AC. Poly(lactide-co-glycolide) Microspheres for MRI-Monitored delivery of sorafenib in a rabbit VX2 model. Biomaterials. 2015.
173. Xiao S, Duncan FE, Bai L, Nguyen CT, Shea LD, Woodruff TK. Size-specific follicle selection improves mouse oocyte reproductive outcomes. Reproduction. 2015.
172. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Comm. 2015.
171. Wood CD, Vijayvergia M, Miller FH, Carroll T, Fasanati C, Shea LD, Catherine Brinson L, Woodruff TK. Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo. Acta Biomater. 2015.
170. Weiss MS, Bernabe BP, Shin S, Asztalos S, Dubbury SJ, Mui MD, Bellis AD, Bluver D, Tonetti DA, Saez-Rodriguez J, Broadbelt LJ, Jeruss JS, Shea LD. Dynamic transcription factor activity quantification for revealing the mechanisms of ErbB2 activity and targeted therapeutics in 3D cancer models. Integr Biol (Camb). 2014.
169. Tarasewicz E, Rivas L, Hamdan R, Dokic D, Parimi V, Bernabe BP, Thomas A, Shea LD, Jeruss JS. Inhibition of CDK-mediated phosphorylation of Smad3 results in decreased oncogenesis in triple negative breast cancer cells. Cell Cycle. 2014.
168. Bryant J, Hlavaty KA, Zhang X, Yap WT, Zhang L, Shea LD, Luo X. Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. Biomaterials. 2014.
167. Xu J, Xu M, Bernuci MP, Fisher TE, Shea LD, Woodruff TK, Zelinski MB, Stouffer RL. Primate follicular development and oocyte maturation in vitro. Adv Exp Med Biol. 2013.
166. Tagler D, Makanji Y, Tu T, Bernabé BP, Lee R, Zhu J, Kniazeva E, Hornick JE, Woodruff TK, Shea LD. Promoting extracellular matrix remodeling via ascorbic acid enhances the survival of primary ovarian follicles encapsulated in alginate hydrogels. Biotech Bioeng. 2014.
165. Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, Shea LD, Woodruff TK. Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet. 2014.
164. Shea LD, Woodruff TK, Shikanov A. Bioengineering the ovarian follicle microenvironment. Annu Rev Biomed Eng. 2014.
163. Thomas AM, Gomez AJ, Palma JL, Yap WT, Shea LD. Heparin-chitosan nanoparticle functionalization of porous poly(ethylene glycol) hydrogels for localized lentivirus delivery of angiogenic factors. Biomaterials. 2014.
162. Thomas AM, Shea LD, Cryotemplation for the Rapid Fabrication of Porous, Patternable Photopolymerized Hydrogels J. Mater. Chem. B. 2014.
161. Yap WT, Song WK, Chauhan N, Scalise PN, Agrawal R, Shea LD. Quantification of particle-conjugated or -encapsulated peptides on interfering reagent backgrounds. BioTechniques. 2014.
160. Smith R, Shikanov A, Kniazeva E, Ramadurai D, Woodruff TK, Shea LD. Fibrin mediated delivery of an ovarian follicle pool in a mouse model of infertility. Tissue Engineering Part A. 2014.
159. McCarthy DP, Hunter ZN, Chackerian B, Shea LD, Miller SD. Targeted Immunomodulation Using Protein Coated Nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014.
158. Duncan MT, Shin S, Wu JJ, Mays Z, Weng S, Bagheri N, Miller WM, Shea LD. Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocyte and erythrocyte differentiation. Biotech and Bioeng. 2014.
157. Hunter Z, McCarthy DP, Yap WT, Harp CT, Getts DR, Shea LD, Miller SD. A biodegradable nanoparticles platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease. ACS Nano. 2014.
156. Thomas AM*, Seidlits SK*, Goodman AG, Kukushliev TV, Hassani DM, Cummings BJ, Anderson AJ, Shea LD. Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integrative Biology, Integr. Biol. 2014.
155. Makanji Y, Tagler D, Pahnke J, Shea LD, Woodruff TK. Hypoxia-mediated carbohydrate metabolism and transport promotes early stage murine follicle growth and survival. Am J Pysiol Endocrinol Metab. 2014.
154. Chen J, Sheu AY, Li W, Zhang Z, Kim DH, Lewandowski RJ, Omary RA, Shea LD, Larson AC. Poly(lactide-co-glycolide) Microspheres for MRI-Monitored Transcatheter Delivery of Sorafenib to Liver Tumors. J Control Release. 2014.
153. Getts DR, Terry RL, Getts MT, Deffrasnes C, Muller M, van Vreden C, Ashhurst TM, Chami B, McCarthy D, Wu H, Ma J, Martin A, Wu B, Kansas GS, Kuhn J, Hafezi W, Campbell IL, Shea LD, Reilly D, Say J, Brown L, White MY, Witting P, Cordwell SJ, Chadban S, Thorp EB, Bao S, Miller SD, King NJC. Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine. 2014.
152. Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, Shea LD. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 2014.
151. Boehler RM, Kuo R, Shin S, Goodman AG, Pilecki MA, Gower RM, Leonard JN, Shea LD. Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype. Biotech Bioeng. 2014.
150. Hlavaty KA, Gibly RF, Zhang X, Rives CB, Graham JG, Luo X, Lowe WL, Shea LD. Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. Am J Transplantation. 2014.
149. Getts DR, Martin AJ, McCarthy DP, Terry RL, Hunter ZN, Yap WT, Getts M, Pleiss M, Luo X, King NJ, Shea LD, Miller SD. Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. Nat Biotechnol. 2012.
148. Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, LD Shea, Penzes P, Ravosa MJ, Stack MS. Matrix rigidity activates Wnt signaling through down-reuglation of Dickkopf-1 protein. J Biol Chem. 2013.
147. Waimey KE, Duncan FE, Su HI, Smith K, Wallach H, Jona K, Coutifaris C, Gracia CR, Shea LD, Brannigan RE, Chang RJ, Zelinski MB, Stouffer RL, Taylor RL, Woodruff TK. Future directions in oncofertility and fertility preservation: a report from the 2011 oncofertility consortium conference. J. Adolesc Young Adult Oncol. 2013.
146. Thomas AM, Kubilius MB, Holland SJ, Seidlits SK, Boehler RM, Anderson AJ, Cummings BJ, Shea LD. Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury. Biomaterials. 2013.
145. Tagler D, Makanji Y, Anderson NR, Woodruff TK, Shea LD. Supplemented αMEM/F12-based medium enables the survival and growth of primary ovarian follicles encapsulated in alginate hydrogels. Biotechnol Bioeng. 2013.
144. Thomas AM, Shea LD. Polysaccharide-modified scaffolds for controlled lentivirus delivery in vitro and after spinal cord injury. J Control Release. 2013.
143. Boehler RM, Shin S, Fast AG, Gower RM, Shea LD. A PLG/HAp composite scaffold for lentivirus delivery. Biomaterials. 2013.
142. Seidlits SK, Gower RM, Shepard JA, Shea LD. Hydrogels for lentiviral gene delivery. Expert Opinion on Drug Delivery. 2013.
141. Yap WT, Salvay DM, Silliman MA, Zhang X, Bannon ZG, Kaufman DB, Lowe Jr. WL, Shea LD. Collagen IV-Modified Scaffolds Improve Islet Survival and Function and Reduce Time to Euglycemia. Tissue Eng Part A. 2013.
140. Hornick JE, Duncan FE, Shea LD, Woodruff TK. Multiple follicle culture supports primary follicle growth through paracrine-acting signals. Reproduction. 2013.
139. Brito IR, Lima IMT, Xu M, LD Shea LD, Woodruff TK, Figueiredo JR. Three-dimensional systems for in vitro follicular culture: overview of alginate-based matrices. Reprod Fertil Dev. 2014.
138. Siletz A, Schnabel M, Kniazeva E, Schumacher AJ, Shin S, Jeruss JS, Shea LD. Dynamic Transcription Factor Networks in Epithelial-Mesenchymal Transition in Breast Cancer Models. PLoS One. 2013.
137. Tuinstra HM, Goodman AG, Holland SJ, Boehler RM, Zelivyanskaya ML, Margul DJ, Cummings BJ, Anderson AJ, Shea LD. Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration. Tissue Eng Part A. 2014.
136. Graham JG, Zhang X, Goodman A, Pothoven K, Houlihan J, Wang S, Gower RM, Luo X, Shea LD. PLG Scaffold Delivered Antigen-Specific Regulatory T cells Induce Systemic Tolerance in Autoimmune Diabetes. Tissue Eng Part A. 2013.
135. Skory RM, Bernabé BP, Galdones E, Broadbelt LJ, Shea LD, Woodruff TK. Microarray analysis identifies COMP as the most differentially regulated transcript throughout in vitro follicle growth. Mol Reproduction and Dev. 2013.
134. Ahn RW, Barrett SL, Raja MR, Jozefik JK, Spaho L, Chen H, Bally MB, Mazar AP, Avram MJ, Winter JN, Gordon LI, Shea LD, O’Halloran TV, Woodruff TK. Nano-encapsulation of arsenic trioxide enhances efficacy in a murine lymphoma model while minimizing chemotherapeutic fertotoxicity in vitro and in vivo. PLoS One. 2013.
133. Mutharasan P, Galdones E, Bernabé BP, Garcia O, Jafari N, Shea LD, Woodruff TK, Legro RS, Dunaif A, Urbanek M. Evidence for Chromosome 2p16.3 Polycystic Ovary Syndrome Susceptibility Locus in Affected Women of European Ancestry. Journal of Clinical Endocrinology & Metabolism. 2013.
132. Tuinstra HM, DuCommun M, Briley WE, Shea LD. Gene delivery to overcome astrocyte inhibition of axonal growth: an in vitro model of the glial scar. Biotech & Bioeng. 2013.
131. Shepard JA, Virani FR, Goodman AG, Gossett TD, Shin S, Shea LD. Hydrogel macroporosity and the prolongation of transgene expression and the enhancement of angiogenesis. Biomaterials. 2012.
130. Siletz A, Kniazeva E, Jeruss JS, Shea LD. Transcription Factor Networks in Invasion-Promoting Breast Carcinoma-Associated Fibroblasts. Cancer Microenvironment. 2013.
129. Jen MC, Baler K, Hood AR, Shin S, Shea LD, Ameer GA. Sustained, localized transgene expression mediated from lentivirus-loaded biodegradable polyester elastomers. J Biomed Mater Res A. 2013.
128. Bellis AD, Bernabe BP, Weiss MS, Shin S, Weng S, Broadbelt LJ, Shea LD. Dynamic Transcription Factor Activity Profiling in 2D and 3D Cell Cultures. Biotechnol Bioeng. 2013.
127. Duncan FE, Hornick JE, Lampson MA, Schultz RM, Shea LD, Woodruff TK. Chromosome cohesion decreases in human eggs with advanced maternal age. Aging Cell. 2012.
126. Hornick JE, Duncan FE, Shea LD, Woodruff TK. Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro. Hum Reprod. 2012.
125. Weiss MS, Bernabé BP, Shikanov A, Bluver DA, Mui MD, Shin S, Broadbelt LJ, Shea LD, The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells. Biomaterials. 2012.
124. Parrish EM, Siletz A, Xu M, Woodruff TK, Shea LD. Gene expression in mouse ovarian follicle development in vivo versus an ex vivo alginate culture system. Reproduction. 2011.
123. Tuinstra H, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast A, Ko S, Margul DJ, Bartels AK, Boehler RM, Cummings BJ, Anderson AJ, Shea LD. Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury. Biomaterials. 2012.
122. Gibly RF, Zhang X, Lowe Jr. WL, Shea LD. Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice. Cell Transplant. 2013.
121. Kidd ME, Shin S, Shea LD. Fibrin hydrogels for lentiviral gene delivery in vitro and in vivo. J Control Release. 2012.
120. Boehler RM, Graham JG, Shea LD. Tissue engineering tools for modulation of the immune response. Biotechniques. 2011.
119. Gibly RF, Zhang X, Graham MK, Hering BJ, Kaufman DB, Lowe WL, Shea LD. Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models. Biomaterials. 2011.
118. Gower RM, Shea LD. Biomaterial Scaffolds for Controlled, Localized Gene Delivery of Regenerative Factors. Advances Wound Care. 2013.
117. Tagler D, Tu T, Smith RM, Anderson NR, Tingen CM, Woodruff TK, Shea LD. Embryonic fibroblasts enable the culture of primary ovarian follicles within alginate hydrogels. Tissue Engineering. 2012.
116. Shepard JA, Stevans AC, Holland S, Wang CE, Chikanov A, Shea LD. Hydrogel design for supporting neurite outgrowth and promoting gene delivery to maximize neurite extension. Biotech Bioeng. 2012.
115. Shikanov A, Zhang Z, Smith R, Rajan A, Woodruff TK, Shea LD. Fibrin encapsulation and VEGF delivery promotes ovarian graft survival in mice. Tissue Engineering Part A. 2011.
114. Gibly RF, Graham JG, Luo X, Lowe WL, Hering BJ, Shea LD. Advancing islet transplantation: from engraftment to the immune response. Diabetologia. 2011.
113. Jang JH, Schaffer, DV, Shea LD. Engineering biomaterial systems to enhance viral vector gene delivery. Mol Therapy 2011.
112. Hirshfeld-Cytron JE, Duncan FE, Xu M, Jozefik JK, Shea LD, Woodruff TK. Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles. Hum Reprod. 2011.
111. Shikanov A, Xu M, Woodruff TK, Shea LD. A method for ovarian follicle encapsulation and culture in a proteolytically degradable 3 dimensional system. JoVE. 2011.
110. Tingen CM, Kiesewetter SE, Jozefic J, Thomas C, Tagler D, Shea LD, Woodruff TK. A macrophage and theca cell enriched stromal cell population influences growth and survival of immature murine follicles in vitro. Reproduction. 2011.
109. Kheradmand T, Wang S, Gibly RF, Zhang X, Holland S, Tasch J, Graham JG, Kaufman DB, Miller SD, Shea LD, Luo X. Permanent Protection of PLG Scaffold Transplanted Allogeneic Islet Grafts in Diabetic Mice Treated with ECDI-fixed Donor Splenocyte Infusions. Biomaterials. 2011.
108. Shepard JA, Wesson PJ, Wang CE, Stevans AC, Holland S, Chikanov A, Shea LD. Gene therapy vectors with enhanced transfection based on hydrogels modified with affinity peptides. Biomaterials. 2011.
107. Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS. Matrix rigidity activates Wnt signaling through downregulation of dickkopf-1 protein. J Biol Chem. 2012.
106. Xu M, Fazlebas A, Shikanov A, Jackson E, Barrett SL, Hirshefeld-Cytron J, Kiesewetter SE, Shea LD, Woodruff TK. In vitro oocyte maturation and preantral follicle culture from luteal phase baboon ovary produce mature eggs. Biol Reprod. 2011.
105. Aviles M, Shea LD. Hydrogels to modulate lentivirus delivery in vivo from microporous tissue engineering scaffolds. Drug Del Translational Res. 2011.
104. Smith RM, Woodruff TK, Shea LD. Designing follicle-environment interactions with biomaterials. Cancer Treat Res. 2010.
103. Shikanov A, Smith R, Xu M, Woodruff TK, Shea LD. Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture. Biomaterials. 2011.
102. Silber SJ, Woodruff TK, Shea LD. To Transplant or not to Transplant. Cancer Treat Res. 2010.
101. Woodruff TK, Shea LD. A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health. J Assist Reprod Genet. 2010.
100. Weiss MS, Bernabé BP, Broadbelt LJ, Jeruss, JS, Shea LD. Dynamic, large-scale profiling of transcription factor activity from live cells in 3D culture. PLoS One. 2010.
99. Bellis A, Bernabé BP, Weiss MS, Yarrington ME, Barbolina MV, Pannier AK, Jeruss JS, Broadbelt LJ, Shea LD. Cellular Arrays for Large-scale Analysis of Transcription Factor Activity. Biotech and Bioeng. 2011.
98. Barbolina MV, Kim M, Liu Y, Shepard J, Belmadani A, Miller RJ, Shea LD, Stack MS. Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma. Mol Cancer Res. 2010.
97. Barrett SL, Shea LD, Woodruff TK. Noninvasive Index of Cryorecovery and Growth Potential for Human Follicles In Vitro. Biol of Reprod. 2010.
96. Jin S, Lei L, Shea LD, Zelinski MB, Stouffer RL, Woodruff TK. Markers of growth and development in primate primordial follicles are preserved after slow cryopreservation. Fertil Steril. 2010.
95. Shin S, Tuinstra HM, Salvay DM, Shea LD. Phosphatidylserine immobilization of lentivirus for localized gene transfer. Biomaterials. 2010.
94. Salvay DM, Zelivyanskaya M, Shea LD. Gene delivery by surface immobilization of plasmid to tissue engineering scaffolds. Gene Therapy. 2010.
93. Shepard JA, Huang A, Shikanov A, Shea LD. Balancing cell migration with matrix degradation enhances gene delivery to cells cultured three-dimensionally within hydrogels. J Control Release. 2010.
92. Smitz J, Dolmans MM, Donnez J, Fortune JE, Hovatta O, Jewgenow K, Picton HM, Plancha C, Shea LD, Stouffer RL, Telfer EE, Woodruff TK, Zelinski MB. Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation. Hum Reprod Update. 2010.
91. De Laporte L, des Rieux A, Zelivyanskaya ML, De Clerck NM, Postnov AA, Shea LD. Vascular endothelial growth factor and fibroblast growth factor 2 delivery from spinal cord bridges to enhance angiogenesis following injury. JBMR A, 2011.
90. De Laporte L, Huang A, Ducommun MM, Zelivyanska ML, Aviles MO, Adler AF, Shea LD. Patterned transgene expression in multiple channel bridges after spinal cord injury. Acta Biomaterialia. 2010.
89. Aviles MO, Lin CH, Zelivyanskaya M, Graham JG, Boehler R, Messersmith PB, hea LD. The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds. Biomaterials. 2010.
88. Shin S, Shea LD. Lentivirus immobilization to nanoparticles for enhanced and localized delivery from hydrogels. Mol Therapy. 2010.
87. Rea JC, Gibly RF, Davis NE, Barron AE, Shea LD. Engineering Surfaces for Substrate-Mediated Gene Delivery using Using Recombinant Proteins. Biomacromolecules. 2009.
86. Huang GT, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, Shi S. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A. 2010.
85. Shin S, Salvay DM, Shea LD. Lentivirus delivery by adsorption to tissue engineering scaffolds. JBMR A. 2010.
84. Shikanov A, Xu M, Woodruff TK, Shea LD. Interpenetrating Fibrin-Alginate Matrices for in vitro Ovarian Follicle Development. Biomaterials. 2009.
83. Roh J, Bae J, Lee K, Mayo K, Shea L, Woodruff TK. Regulation of Wilms’ tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary. Fertil Steril. 2009.
82. Yang Y, De Laporte L, Zelivyanskaya ML, Whittlesey KJ, Anderson AJ, Cummings BJ, Shea LD. Multiple channel bridges for spinal cord injury: cellular characterization of host response. Tissue Eng. 2009.
81. Murthi M, Shea LD, Snurr RQ. Numerical Problems and Agent-Based Models for a Mass Transfer Course. Chem Eng Educ. 2009.
80. Tingen CM, Bristol-Gould SK, Kiesewetter SE, Wellington JT, Shea LD, Woodruff TK. Pre-pubertal Primordial Follicle Loss is Not Due to Classical Apoptotic Pathways. Biol Reprod. 2009.
79. Barbolina M, Shea LD, Stack S. Downregulation of Connective Tissue Growth Factor by Three-Dimensional Matrix Enhances Ovarian Carcinoma Cell Invasion. Int J Cancer. 2009.
78. Zhang X, Tang H, Hoshi R, De Laporte L, Qiu H, Xu X, Shea LD, Ameer G. Sustained transgene expression via citric acid-based polyester elastomers. Biomaterials. 2009.
77. Jin SY, Lei L, Shikanov A, Shea LD. A novel two-step strategy for in vitro culture of early-stage ovarian follicles in the mouse. Fertility and Sterility. 2010.
76. Xu M, West ER, Stouffer RL, Shea LD, Woodruff TK, Zelinski MB. Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles. Biol Reprod. 2009.
75. Xu M, Barrett SL, West-Farrell E, Kondapalli LA, Kiesewetter SE, Shea LD, Woodruff TK. In vitro Grown Human Ovarian Follicles from Cancer Patients Support Healthy Oocyte Growth. Hum Reprod Epub. 2009.
74. Houchin-Ray T, Zelivyanskaya M, Huang A, Shea LD. Non-viral gene delivery transfection profiles influence neuronal architecture in an in vitro co-culture model. Biotech and Bioeng. 2009.
73. Xu M, Banc A, Woodruff TK, Shea LD. Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles. Biotech Bioeng. 2009.
72. des Rieux A, Shikanov A, Shea LD. Fibrin hydrogels for non-viral vector delivery in vitro. J Cont Rel. 2009.
71. De Laporte L, Yan AL, Shea LD. Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury. Biomaterials. 2009.
70. West-Farrell E, Xu M, Woodruff TK, Shea LD. The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles. Biol Reprod. 2009.
69. Bengali Z, Rea JC, Gibly RF, Shea LD. Efficacy of immobilized polyplexes and lipoplexes for substrate-mediated gene delivery. Biotechnol Bioeng. 2009.
68. De Laporte L, Yang Y, Zelivyanskaya ML, Cummings BJ, Anderson AJ, Shea LD. Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury. Mol Ther. 2009.
67. West E, Zelinski MB, Kondapalli LA, Gracia C, Chang J, Coutifaris C, Critser J, Stouffer RL, Shea LD, Woodruff TK. Preserving female fertility following cancer treatment: current options and future possibilities. Pediatric Blood and Cancer. 2009.
66. Rea JC, Gibly RF, Barron AE, Shea LD. Self-Assembling Peptide-Lipoplexes for Substrate-Mediated Gene Delivery. Acta Biomaterialia. 2009.
65. Rives CB, des Rieux A, Zelivyanskaya M, Stock S, Lowe WL, Shea LD. Layered PLG Scaffolds for In Vivo Plasmid Delivery. Biomaterials. 2009.
64. Houchin-Ray T, Huang A, West ER, Zelivyanskaya M, Shea LD. Spatially Patterned Gene Expression for Guided Neurite Extension. J. Neuro. Res. 2009.
63. Barbolina MV, Adley BP, Kelly DL, Fought AJ, Scholtens DM, Shea LD, Stack MS. Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma. Lab Invest. 2008.
62. Rea JC, Barron AE, Shea LD. Peptide-mediated lipofection is governed by lipoplex physical properties and the density of surface-displayed amines. J Pharm Sci. 2008.
61. Barbolina MV, Adley BP, Shea LD, Stack MS. Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion. Cancer. 2008.
60. Salvay DM, Rives CB, Zhang X, Chen F, Kaufman DB, Lowe WL, Shea LD. Extracellular Matrix Proteins Adsorbed To PLG Microporous Scaffolds Promote The Reversal Of Diabetes Following Extrahepatic Islet Transplantation. Transplantation. 2008.
59. Pannier AK, Wieland J, Shea LD. Surface Polyethylene Glycol Enhances Substrate-Mediated Gene Delivery by Nonspecifically- Bound Complexes. Acta Biomaterialia. 2008.
58. Woodruff TK, Shea LD. The Role of the Extracellular Matrix in Ovarian Follicle Development. Reprod Sci. 2007.
57. Xu M, Woodruff TK, Shea LD. Bioengineering and the ovarian follicle. Cancer Treat Res. 2007.
56. Weiss MS, Jeruss JS, Shea LD, Tunable Microenvironments for Three-Dimensional Culture in Cancer Research. The Journal of the Roert H. Lurie Comprehensive Cancer Center. 2007.
55. West E, Xu M, Woodruff TK, Shea LD. Physical properties of alginate hydrogels and their effects on in vitro follicle development. Biomaterials. 2007.
54. West ER, Shea LD, Woodruff TK. Engineering the follicle microenvironment. Semin Reprod Med. 2007.
53. Bengali Z, Rea JC, Shea LD. Gene Expression and internalization following vector immobilization to proteins: dependence on protein identity and density. J Gene Med. 2007.
52. Pannier AK, Ariazi E, Bellis AD, Bengali Z, Jordan VC, Shea LD. Bioluminescence Imaging for Assessment and Normalization in Transfected Cell Arrays. Biotech and Bioeng. 2007.
51. De Laporte L, Shea LD. Matrices and Scaffolds for DNA Delivery in Tissue Engineering. Adv. Drug Del. Reviews. 2007.
50. Shea LD. Back to the science of stem cell research – CHI’s 2nd annual meeting. iDrugs. 2006.
49. Houchin-Ray T, Swift LA, Jang JH, Shea LD. Patterned PLG substrates for localized DNA delivery and directed neurite extension. Biomat. 2007.
48. Lerch TF, Xu M, Jardetzky TS, Mayo KE, Radhakrishnan I, Kazer R, Shea LD, Woodruff TK. The Structures that Underlie Normal Reproductive Function. Mol Cell Endo. 2007.
47. Wieland J, Houchin-Ray TL, Shea LD. Non-viral vector delivery from PEG-hyaluronic acid hydrogels. J Cont Rel. 2007.
46. Houchin-Ray TL, Whittlesey KJ, Shea LD. Spatially Patterned Gene Delivery for Localized Neuron Survival and Neurite Extension. Mol. Ther. 2007.
45. Cheema SK, Chen E, Shea LD, Mathur AB. Regulation and Guidance of Cell Behavior for Tissue Regeneration via the siRNA Mechanism. Wound Repair Regen. 2007.
44. Xu M, West E, Shea LD, Woodruff TK. Identification of a Stage-Specific Permissive in vitro Culture Environment For Follicle Growth and Oocyte Development. Biol Reprod. 2006.
43. Berkholtz CB, Shea LD, Woodruff TK. Extracellular matrix functions in follicle maturation. Semin Reprod Med. 2006.
42. Berkholtz CB, Lai BE, Woodruff TK, Shea LD. Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis. Histochem Cell Biol. 2006.
41. Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Cook RW, Kipp JL , Shea LD, Mayo KE, Woodruff TK. Postnatal regulation of germ cells by activin: The establishment of the initial follicle pool. Dev. Biol. 2006.
40. Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD, Woodruff TK. Fate of the initial follicle pool: Empirical and mathematical evidence supporting its sufficiency for adult fertility. Dev. Biol. 2006.
39. Xu M, Kreeger PK, Shea LD, Woodruff TK. Tissue-Engineered Follicles Produce Live, Fertile Offspring. Tissue Eng. 2006.
38. Nieman CL, Kazer R, Brannigan RE, Zoloth LS, Chase-Lansdale PL, Kinahan K, Dilley KJ, Roberts D, Shea LD, Woodruff TK. Cancer survivors and infertility: a review of a new problem and novel answers. J Support Oncol. 2006.
37. Jang JH, Shea LD. Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression. J Control Release. 2006.
36. Blomeier H, Zhang X, Rives C, Hughes E, Baker M, Brissova M, Powers AC, Kaufman DB, Shea LD, Lowe Jr. WL. Polymer Scaffolds as Synthetic Microenvironments for Extrahepatic Islet Transplantation. Transplantation. 2006.
35. Salvay D, Shea LD. Inductive tissue engineering by protein and DNA releasing scaffolds. Mol Biosyst. 2006.
34. Jang JH, Houchin T, Bengali Z, Shea LD. Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery. J Biomed Mater Res A. 2006.
33. De Laporte L, Cruz-Rea J, Shea LD. Design of modular non-viral gene therapy vectors. Biomaterials. 2006.
32. Kreeger PK, Deck JW, Woodruff TK, Shea LD. The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels. Biomaterials. 2006.
31. Whittlesey KJ, Shea LD. Nerve growth factor expression by PLG-mediated lipofection. Biomaterials. 2006.
30. Pannier AK, Anderson BC, Shea LD. Substrate-Mediated Delivery from Self-Assembled Monolayers: Effect of Surface Ionization, Hydrophilicity, and Patterning. Acta Biomat. 2005.
29. Jang JH, Rives CB, Shea LD. Plasmid Delivery in Vivo from Porous Tissue-Engineering Scaffolds: Transgene Expression and Cellular Transfection. Mol Ther. 2005.
28. Bengali Z, Shea LD. Gene Delivery by Immobilization to Cell-Adhesive Substrates. MRS Bulletin. 2005.
27. Kreeger PK, Fernandes NN, Woodruff TK, Shea LD. Regulation of Murine Follicle Development by Follicle Stimulating Hormone in a Three-Dimensional In Vitro Culture System is Dependent on Follicle Stage and Dose. Biol. Reprod. 2005.
26. Yang Y, De Laporte L, Rives CB, Jang JH, Shull KR, Shea LD. Neurotrophin releasing single and multiple lumen nerve conduits. J. Cont. Rel. 2005.
25. Bengali Z, Pannier A, Segura T, Anderson BA, Jang JH, Mustoe TA, Shea LD. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol. Bioeng. 2005.
24. Segura T, Chung PH, Shea LD. DNA Delivery from Hyaluronic Acid-Collagen Hydrogels via a substrate-mediated approach. Biomaterials. 2005.
23. Segura T, Anderson BC, Chung PH, Webber RE, Shull KR, Shea LD. Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern. Biomaterials. 2005.
22. Jang JH, Houchin TL, Shea LD. Gene delivery from polymer scaffolds for tissue engineering. Exp. Rev. Med. Dev. 2004.
21. Pannier AK, Shea LD, Controlled release systems for non-viral vectors. The Journal of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. 2004.
20. Whittlesey KJ, Shea LD. Delivery systems for small molecule drugs, proteins, and DNA: the neuroscience/biomaterial interface. Expt Neurol. 2004.
19. Shea LD, Houchin TL. Modular design of non-viral vectors with bioactive components. Trends in Biotech. 2004.
18. Pannier AK, Shea LD. Controlled release systems for DNA delivery. Molecular Therapy. 2004.
17. Segura T, Volk M, Shea LD. Substrate-Mediated DNA Delivery: Role of the Cationic Polymer Structure and Extent of Modification. J Cont Rel. 2003.
16. Kreeger PK, Woodruff TK, Shea LD. Murine granulose cells morphology and function are regulated by a synthetic RGD matrix. Mol. and Cell. Endocrin. 2003.
15. Pangas SA, Saudye H, Shea LD, Woodruff TK. A Novel Approach for the Three Dimensional Culture of Granulosa Cell-Oocyte Complexes. Tissue Eng 2003.
14. Jang J, Shea LD. Controllable delivery of non-viral DNA from porous scaffolds. J. Cont. Rel. 2003.
13. Segura T, Shea LD. Surface-Tethered DNA Complexes for Enhanced Gene Delivery. Bioconj. Chem. 2002.
12. Nof M, Shea LD, Drug-releasing scaffolds fabricated from drug-loaded microspheres. J. Biomed. Mat. Res. 2002.
11. Shea LD, Mooney DJ. Nonviral DNA delivery from polymeric systems. Methods Mol Med. 2001.
10. Shea LD, Neubig RR, and Linderman JJ. Timing is everything: the role of kinetics in G-protein activation. Life Sciences. 2000
9. Shea LD, Wong D, Franceschi RT, Mooney DJ. Engineered bone development from a pre-osteoblast cell line on three-dimensional scaffolds. Tissue Engineering. 2000.
8. Eiselt P, Yeh J, Latvala RK, Shea LD, Mooney DJ. Porous carriers for biomedical applications based on alginate hydrogels. Biomaterials. 2000.
7. Sheridan M, Shea LD, Peters MC, Mooney DJ. Bioabsorbable Polymer Scaffolds for Tissue Engineering Capable of Sustained Growth Factor Delivery. J. Cont. Rel. 2000.
6. Peters MC, Shea LD, Mooney DJ. Protein and plasmid DNA delivery from tissue engineering matrices. ACS Polymer preprints. 1999.
5. Shea LD, Smiley E, Bonadio J, Mooney DG. DNA delivery from polymer matrices for tissue engineering. Nature Biotechnology. 1999.
4. Shea LD, Linderman JJ. Compartmentalization of Receptors and Enzymes Affects Activation for a Collision Coupling Mechanism. J. Theor. Biol. 1998.
3. Shea LD, Omann GM, Linderman JJ. Calculation of Diffusion-Limited Kinetics for the Reactions in Collision Coupling and Receptor Crosslinking. Biophysical J. 1997.
2. Shea LD, Linderman JJ. Mechanistic Model of G-Protein Signal Transduction: Determinants of Efficacy and Effect of Precoupled Receptors. Biochem. Pharm. 1997.
1. Shea LD, Feke DL, and Landau U. Counteracting Flow Electrophoresis: A Technique for Separating Biochemicals or Charged Macromolecules. Biotechnol. Prog. 1994